SCHEMBL10695025

SCHEMBL10695025

N#Cc1cc(I)c(O)c(I)c1C#N

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TTR P02766 3/20 0.48
ALB P02768 2/20 0.48
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34
CACNA1B Q00975 1/20 0.34
APBA1 Q02410 1/20 0.34
SLC22A12 Q96S37 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10495691 0.83 TTR (0.52) TTRALBMEN1KMT2AKDM4E
SCHEMBL24871886 0.77 TRPV4 (0.32) TTRALBMEN1KMT2AKDM4E
SCHEMBL10876678 0.77 MEN1 (0.42) TTRALBMEN1KMT2AKDM4E
SCHEMBL16258110 0.73 TTR (0.34) TTRALB
SCHEMBL10763743 0.70 TDP1 (0.40) TTRALBSLC22A12
SCHEMBL28632561 0.70 TTR (0.39) TTRALBMEN1KMT2AKDM4E
SCHEMBL7103109 0.70 TTR (0.56) TTRALBMEN1KMT2ASLC22A12
SCHEMBL23957246 0.69 TTR (0.39) TTRALBMEN1KMT2AKDM4E
SCHEMBL28632562 0.69 TTR (0.42) TTRALB
SCHEMBL15492122 0.69 TTR (0.42) TTRALBMEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0251012-A2 N-sulfenyl-2-trifluoromethyl benzimidazoles BAYER AG (DE) 1988-01-07 EP disclosed