Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696064 | 0.95 | MEN1 (0.47) | MEN1KMT2AATMPDE3BPDE3A | |
| SCHEMBL10694972 | 0.87 | MEN1 (0.40) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL10699478 | 0.84 | MEN1 (0.41) | MEN1KMT2AATMPDE3BPDE3A | |
| SCHEMBL10699875 | 0.82 | MEN1 (0.40) | MEN1KMT2AATMPDE3BPDE3A | |
| SCHEMBL10695521 | 0.81 | CYP11B2 (0.53) | ATMCYP11B1CYP11B2DHFRKIT | |
| SCHEMBL10695097 | 0.80 | PARP1 (0.40) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL10701679 | 0.80 | MEN1 (0.41) | MEN1KMT2AATMPDE3BPDE3A | |
| SCHEMBL10699877 | 0.79 | MEN1 (0.41) | MEN1KMT2AATMPDE3BPDE3A | |
| SCHEMBL10694340 | 0.75 | CA12 (0.50) | MEN1KMT2ACA12CA9DHFR | |
| SCHEMBL10694143 | 0.75 | ALDH1A1 (0.48) | ATMPDE3BPDE3AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |