Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | PNP | P00491 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10701181 | 0.91 | AURKA (0.48) | LMNATSHRKDM4ESMN1; SMN2AURKA | |
| SCHEMBL10693758 | 0.83 | AURKA (0.41) | TSHRKDM4ESMN1; SMN2AURKAAURKB | |
| SCHEMBL10695357 | 0.80 | AURKA (0.46) | KDM4ESMN1; SMN2AURKAAURKBADORA2B | |
| SCHEMBL10696997 | 0.77 | AURKA (0.48) | KDM4ESMN1; SMN2AURKAAURKBHPGD | |
| SCHEMBL13341639 | 0.76 | NPC1 (0.43) | LMNAKDM4ESMN1; SMN2AURKAAURKB | |
| SCHEMBL13341637 | 0.76 | RAB9A (0.43) | LMNATSHRSMN1; SMN2AURKAAURKB | |
| SCHEMBL10696394 | 0.76 | PDE4A (0.52) | KDM4ESMN1; SMN2AURKAAURKBPOLB | |
| SCHEMBL13341418 | 0.75 | MEN1 (0.43) | TSHRAURKAAURKBKMT2AMEN1 | |
| SCHEMBL13341650 | 0.75 | POLB (0.42) | AURKAAURKBPOLBKMT2ATDP1 | |
| SCHEMBL10567130 | 0.75 | TSHR (0.52) | LMNATSHRKDM4ESMN1; SMN2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |