Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | PNP | P00491 | 2/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10695723 | 0.83 | LMNA (0.44) | AURKAAURKBPNPALDH1A1HPGD | |
| SCHEMBL10695197 | 0.80 | AURKA (0.46) | AURKAAURKBALDH1A1HPGDKDM4A | |
| SCHEMBL13341286 | 0.79 | AURKA (0.41) | AURKAAURKBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL10696394 | 0.76 | PDE4A (0.52) | AURKAAURKBALDH1A1HPGDHSD17B10 | |
| SCHEMBL12207656 | 0.76 | AURKA (0.40) | AURKAAURKBPNPALDH1A1 | |
| SCHEMBL10695665 | 0.75 | RIPK1 (0.48) | AURKAAURKBTSHRKDM4ESMN1; SMN2 | |
| SCHEMBL13341645 | 0.75 | LMNA (0.40) | AURKAAURKBALDH1A1TSHRMAPK1 | |
| SCHEMBL2488149 | 0.74 | AURKA (0.48) | AURKAAURKBALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL2485583 | 0.74 | AURKA (0.48) | AURKAAURKBHPGDSMN1; SMN2KMT2A | |
| SCHEMBL2486921 | 0.74 | AURKA (0.48) | AURKAAURKBNPSR1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |