Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | IDE | P14735 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CCL2 | P13500 | 1/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700358 | 0.89 | TNKS2 (0.43) | KMT2ALMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL10700676 | 0.88 | ALDH1A1 (0.38) | KMT2ALMNASMN1; SMN2MAPTRECQL | |
| SCHEMBL10697745 | 0.87 | KMT2A (0.39) | KMT2ASMN1; SMN2MEN1GAAAR | |
| SCHEMBL10697977 | 0.85 | MEN1 (0.36) | KMT2ALMNASMN1; SMN2MAPTRECQL | |
| SCHEMBL10696186 | 0.81 | KMT2A (0.43) | KMT2ALMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL10699606 | 0.80 | TNKS2 (0.43) | KMT2AMAPTMEN1GAABRD4 | |
| SCHEMBL10698974 | 0.78 | KMT2A (0.37) | KMT2ALMNASMN1; SMN2MAPTRECQL | |
| SCHEMBL10697413 | 0.78 | BMPR1B (0.39) | KMT2ALMNASMN1; SMN2MAPTRECQL | |
| SCHEMBL10699249 | 0.78 | HPGD (0.37) | KMT2ALMNASMN1; SMN2MAPTRECQL | |
| SCHEMBL10698144 | 0.77 | KDM4E (0.39) | TDP1BRD4CCL2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |