Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7684650 | 0.69 | HRH3 (0.68) | HRH3 | |
| SCHEMBL10695752 | 0.69 | HRH3 (0.49) | HRH3MAP3K5APP | |
| SCHEMBL7684647 | 0.69 | HRH3 (0.45) | HRH3MAP3K5APPKDM4ENPC1 | |
| SCHEMBL5280286 | 0.69 | L3MBTL1 (0.59) | EGFRERBB2KDM4ENPC1ALDH1A1 | |
| SCHEMBL8602388 | 0.67 | ESR1 (0.54) | EGFRERBB2NPC1ALDH1A1POLB | |
| SCHEMBL1500236 | 0.67 | KDM4E (0.64) | KDM4ENPC1ALDH1A1POLBGAA | |
| SCHEMBL1500262 | 0.66 | PIK3CG (0.51) | HRH3MAP3K5APPKDM4ENPC1 | |
| SCHEMBL1275299 | 0.66 | EGFR (0.44) | EGFRERBB2KDM4EALDH1A1POLB | |
| SCHEMBL1827424 | 0.65 | EGFR (0.59) | EGFRERBB2KDM4ENPC1ALDH1A1 | |
| SCHEMBL11314840 | 0.64 | EGFR (0.58) | EGFRERBB2KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4727145-A | LOCAL ANESTHETICS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-02-23 | — | — | US | disclosed |