SCHEMBL10695980

SCHEMBL10695980

C=CC(C)Sc1nnc(C(C)C(F)F)c(=O)n1N

nearest known ligand 0.42

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.42
PTGS2 P35354 1/20 0.32
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11716645 0.68 POLB (0.67) POLBPTGS2ALDH1A1
SCHEMBL11717549 0.65 ALDH1A1 (0.42) POLBALDH1A1
SCHEMBL9802350 0.60 ALDH1A1 (0.43) POLBALDH1A1
SCHEMBL9802279 0.57 POLB (0.39) POLBALDH1A1
SCHEMBL11717192 0.56 POLB (0.39) POLBPTGS2ALDH1A1
SCHEMBL11722300 0.53 POLB (0.33) POLB
SCHEMBL11718225 0.51 POLB (0.32) POLB
SCHEMBL11717637 0.51 POLB (0.32) POLB
SCHEMBL11716370 0.51 ALDH1A1 (0.42) POLBALDH1A1
SCHEMBL776865 0.46

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4783531-A Production of S-substituted isothioureas MOBAY CORPORATION (US) 1988-11-08 US disclosed
US-4659819-A Production of S-substituted isothioureas MOBAY CORPORATION (US) 1987-04-21 US disclosed
US-4578463-A Production of S-substituted isothioureas MOBAY CHEMICAL CORPORATION (US) 1986-03-25 US disclosed