Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | CBFB | Q13951 | 13/20 | 0.48 |
| ▸ | METAP1 | P53582 | 5/20 | 0.48 |
| ▸ | METAP2 | P50579 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700349 | 0.89 | AURKA (0.62) | AURKAAURKBCBFBMETAP1METAP2 | |
| SCHEMBL10700210 | 0.86 | CBFB (0.52) | AURKAAURKBCBFBMETAP1METAP2 | |
| SCHEMBL10694210 | 0.85 | PDE4A (0.51) | AURKAAURKBNPC1RAB9AKDM4E | |
| SCHEMBL10700908 | 0.85 | AURKA (0.50) | AURKAAURKBCBFBMETAP1METAP2 | |
| SCHEMBL10695132 | 0.83 | CBFB (0.54) | CBFBMETAP1METAP2NPC1RAB9A | |
| SCHEMBL10696409 | 0.83 | HPGD (0.50) | AURKAAURKBNPC1RAB9AKDM4E | |
| SCHEMBL10696080 | 0.81 | TDP1 (0.50) | AURKAAURKBNPC1RAB9APKM | |
| SCHEMBL5191758 | 0.80 | FGFR1 (0.48) | AURKAAURKBMAPTSMN1; SMN2 | |
| SCHEMBL10697398 | 0.77 | AURKA (0.62) | AURKAAURKBCBFBMETAP1METAP2 | |
| SCHEMBL4509493 | 0.75 | AURKA (0.53) | AURKAAURKBCBFBMETAP1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |