Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 12/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697581 | 0.98 | KEAP1 (0.43) | KEAP1NFE2L2CHRM3SMN1; SMN2L3MBTL1 | |
| SCHEMBL10697753 | 0.94 | L3MBTL1 (0.43) | KEAP1NFE2L2CHRM3SMN1; SMN2L3MBTL1 | |
| SCHEMBL6589388 | 0.80 | KEAP1 (0.61) | KEAP1NFE2L2CHRM3SMN1; SMN2L3MBTL1 | |
| SCHEMBL17490363 | 0.78 | L3MBTL1 (0.50) | KEAP1NFE2L2CHRM3SMN1; SMN2L3MBTL1 | |
| SCHEMBL4213705 | 0.77 | KEAP1 (0.61) | KEAP1NFE2L2CHRM3CHRM2CHRM4 | |
| SCHEMBL4203592 | 0.77 | KEAP1 (0.61) | KEAP1NFE2L2CHRM3CHRM2CHRM4 | |
| SCHEMBL4203042 | 0.77 | KEAP1 (0.61) | KEAP1NFE2L2CHRM3CHRM2CHRM4 | |
| SCHEMBL16500241 | 0.77 | KEAP1 (0.49) | KEAP1NFE2L2CHRM3SMN1; SMN2L3MBTL1 | |
| SCHEMBL16132528 | 0.76 | SMN1; SMN2 (0.48) | KEAP1NFE2L2CHRM3SMN1; SMN2L3MBTL1 | |
| SCHEMBL2788610 | 0.76 | KEAP1 (0.59) | KEAP1NFE2L2CHRM3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0253681-A2 | Cycloalkyl-substituted 4-pyridyl derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-01-20 | — | — | EP | disclosed |