SCHEMBL10697065

SCHEMBL10697065

CC(=O)C(C)(C)c1sccc1C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 1/20 0.39
RIPK1 Q13546 1/20 0.37
POLB P06746 2/20 0.36
NPC1 O15118 6/20 0.35
RAB9A P51151 6/20 0.35
PKM P14618 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
ATM Q13315 1/20 0.35
ALOX5 P09917 2/20 0.35
GAA P10253 3/20 0.33
LMNA P02545 1/20 0.33
PPARG P37231 1/20 0.33
NCOR2 Q9Y618 1/20 0.33
SMN1; SMN2 Q16637 4/20 0.33
HPGD P15428 2/20 0.33
FFAR1 O14842 1/20 0.33
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
GLA P06280 1/20 0.32
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9577296 0.81 GSK3B (0.37) GSK3BRIPK1POLBNPC1RAB9A
SCHEMBL11539034 0.74 GSK3B (0.38) GSK3BRIPK1POLBNPC1RAB9A
SCHEMBL802210 0.73 PKM (0.38) GSK3BRIPK1POLBNPC1RAB9A
SCHEMBL19862530 0.72 NPC1 (0.37) GSK3BRIPK1NPC1RAB9APKM
SCHEMBL3234536 0.72 NPC1 (0.37) GSK3BRIPK1NPC1RAB9APKM
SCHEMBL20909675 0.70 NPC1 (0.35) GSK3BRIPK1NPC1RAB9APKM
SCHEMBL22733836 0.70 CYP2A6 (0.36) GSK3BRIPK1NPC1RAB9APKM
Maleic Acid SCHEMBL9483854 0.69 HCAR2 (0.39) GSK3BRIPK1POLBNPC1RAB9A
SCHEMBL12238628 0.68 ALOX5 (0.34) GSK3BRIPK1NPC1RAB9APKM
SCHEMBL12161061 0.67 NPC1 (0.37) GSK3BNPC1RAB9APKML3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0267435-A1 Substituted aminocetals BAYER AG (DE) 1988-05-18 EP disclosed