Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfacytine SCHEMBL49377 | 0.86 | HTR6 (0.50) | KDM4EALDH1A1TSHRMAPTSMN1; SMN2 | |
| Sulfacytine SCHEMBL28251252 | 0.82 | CA1 (0.48) | KDM4EALDH1A1TSHRUSP2MAPT | |
| Sulfacytine SCHEMBL28122249 | 0.82 | LMNA (0.60) | KDM4EALDH1A1TSHRMEN1MAPT | |
| SCHEMBL9806949 | 0.80 | MAPT (0.43) | HPGDMAPTKMT2ASMN1; SMN2POLB | |
| SCHEMBL11919277 | 0.75 | SMN1; SMN2 (0.54) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL1093465 | 0.70 | KDM4E (0.54) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL29967633 | 0.68 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL6026817 | 0.68 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL822366 | 0.67 | NPSR1 (0.69) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL11915946 | 0.67 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255100-A2 | Use of trimetrexate and its salts for the preparation of pharmaceutical compositions for treating infections of the mycobacterium-avium-intracellulare complex | WARNER-LAMBERT COMPANY (US) | 1988-02-03 | — | — | EP | claimed |
| EP-0255100-A2 | Use of trimetrexate and its salts for the preparation of pharmaceutical compositions for treating infections of the mycobacterium-avium-intracellulare complex | WARNER-LAMBERT COMPANY (US) | 1988-02-03 | — | — | EP | disclosed |