Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699134 | 0.87 | ALDH1A1 (0.38) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL10699780 | 0.84 | BMPR1B (0.37) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL10695102 | 0.80 | KDM4E (0.38) | ALDH1A1KDM4EHPGDCASP1HSD17B10 | |
| SCHEMBL10694302 | 0.79 | KDM4E (0.43) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL10696706 | 0.76 | ALDH1A1 (0.41) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL10691737 | 0.75 | MEN1 (0.36) | ALDH1A1KDM4EGAARAB9AHSD17B10 | |
| SCHEMBL10701783 | 0.74 | KMT2A (0.40) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL10700949 | 0.70 | BMPR1B (0.36) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL10700189 | 0.70 | ALDH1A1 (0.37) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL10697625 | 0.70 | BMPR1B (0.39) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |