Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 3/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27628301 | 0.90 | FOLH1 (0.45) | FOLH1AKT1LTB4RLTB4R2MTNR1A | |
| SCHEMBL27346861 | 0.87 | FOLH1 (0.45) | FOLH1CYP4F2CYP4A11AKT1LTB4R | |
| SCHEMBL7378582 | 0.85 | FOLH1 (0.43) | FOLH1CYP4F2CYP4A11AKT1LTB4R | |
| SCHEMBL534889 | 0.85 | KDM4E (0.50) | FOLH1CYP4F2CYP4A11LTB4RLTB4R2 | |
| SCHEMBL283 | 0.83 | SLC6A3 (0.48) | LTB4R2MEN1ALDH1A1KMT2ASCN1A | |
| SCHEMBL18280658 | 0.83 | CYP4F2 (0.45) | CYP4F2CYP4A11AKT1MEN1ALDH1A1 | |
| SCHEMBL3234150 | 0.82 | CYP4F2 (0.62) | FOLH1CYP4F2CYP4A11MEN1ALDH1A1 | |
| SCHEMBL2487626 | 0.80 | CYP46A1 (0.51) | MTNR1AMTNR1BALDH1A1GRM6 | |
| SCHEMBL30461149 | 0.79 | FOLH1 (0.71) | FOLH1LTB4RLTB4R2MEN1ALDH1A1 | |
| SCHEMBL3234271 | 0.79 | FOLH1 (0.71) | FOLH1LTB4RLTB4R2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115806516-A | Benzyl pentafluoroethylseleno compound and preparation method thereof | 南京理工大学 | 2023-03-17 | — | — | CN | claimed |
| CN-106008357-A | Novel impurity of telmisartan and synthesis method thereof | 浙江华海药业股份有限公司 | 2016-10-12 | — | — | CN | claimed |
| CN-106008356-A | Preparation method for telmisartan | 浙江华海药业股份有限公司 | 2016-10-12 | — | — | CN | claimed |
| CN-115806516-A | Benzyl pentafluoroethylseleno compound and preparation method thereof | 南京理工大学 | 2023-03-17 | — | — | CN | disclosed |
| CN-115108906-A | Novel method for preparing 4 '-bromomethyl- [1,1' -biphenyl ] -2-tert-butyl formate | 临海市华南化工有限公司 | 2022-09-27 | — | — | CN | disclosed |
| CN-112251770-B | Novel electrochemical preparation method of antihypertensive drug telmisartan intermediate | 湖南大学 | 2021-07-27 | — | — | CN | disclosed |
| CN-112251770-A | Novel electrochemical preparation method of antihypertensive drug telmisartan intermediate | 湖南大学 | 2021-01-22 | — | — | CN | disclosed |
| CN-106008357-A | Novel impurity of telmisartan and synthesis method thereof | 浙江华海药业股份有限公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-106008356-A | Preparation method for telmisartan | 浙江华海药业股份有限公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-102229570-B | New method for synthesizing telmisartan intermediates | ZHEJIANG HISUN PHARM CO LTD | 2013-10-16 | — | — | CN | disclosed |
| EP-2445888-B1 | Process for preparing telmisartan | INKE SA (ES) | 2013-08-07 | — | — | EP | disclosed |
| US-5438136-A | Benzo-fused macrocycles promote release of growth hormone | MERCK & CO., INC. (US) | 1995-08-01 | — | — | US | disclosed |
| WO-1995012598-A1 | BENZO-FUSED MACROCYCLES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-05-11 | — | — | WO | disclosed |
| US-5332744-A | Hypotensive, congestive heart failure, intraocular pressure | MERCK & CO., INC. (US) | 1994-07-26 | — | — | US | disclosed |
| EP-0587698-A1 | SUBSTITUTED 1-(2H)-ISOQUINOLINONES BEARING ACIDIC FUNCTIONAL GROUPS AS ANGIOTENSIN II ANTAGONISTS | MERCK & CO. INC. (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5274104-A | N-substituted heterocyclic derivatives useful in the treatment of cardiovascular disorders | ELF SANOFI, A FRENCH CORP. (FR) | 1993-12-28 | — | — | US | disclosed |
| US-5238942-A | Hypotensive agents | MERCK & CO., INC. (US) | 1993-08-24 | — | — | US | disclosed |
| CN-1070912-A | Imidazopyridine derivatives and preparation method thereof | TANABE SEIYAKU CO (JP) | 1993-04-14 | — | — | CN | disclosed |
| WO-1992020660-A1 | SUBSTITUTED 1-(2H)-ISOQUINOLINONES BEARING ACIDIC FUNCTIONAL GROUPS AS ANGIOTENSIN II ANTAGONISTS | MERCK & CO., INC. (US) | 1992-11-26 | — | — | WO | disclosed |
| CN-1065063-A | 1-Biphenylmethylimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1992-10-07 | — | — | CN | disclosed |