Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.31 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696432 | 0.94 | AURKA (0.48) | AURKAAURKBNPBWR1MAPTALDH1A1 | |
| SCHEMBL10697449 | 0.90 | AURKA (0.57) | AURKAAURKBNPBWR1MAPTALDH1A1 | |
| SCHEMBL10693690 | 0.80 | PDE4A (0.51) | AURKAAURKBALDH1A1KDM4EGAA | |
| SCHEMBL10695935 | 0.79 | AURKA (0.48) | AURKAAURKBSMN1; SMN2RAB9AMEN1 | |
| SCHEMBL2491911 | 0.79 | AURKA (0.51) | AURKAAURKBMAPTALDH1A1KDM4E | |
| SCHEMBL10695107 | 0.78 | AURKA (0.46) | AURKAAURKBNPBWR1ALDH1A1KDM4E | |
| SCHEMBL10695197 | 0.78 | AURKA (0.46) | AURKAAURKBALDH1A1KDM4EGAA | |
| SCHEMBL10695207 | 0.78 | AURKB (0.46) | AURKAAURKBNPBWR1SMN1; SMN2RAB9A | |
| SCHEMBL10695357 | 0.78 | AURKA (0.46) | AURKAAURKBMAPTALDH1A1KDM4E | |
| SCHEMBL13341286 | 0.78 | AURKA (0.41) | AURKAAURKBSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |