Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.48 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697347 | 0.94 | AURKA (0.46) | AURKAAURKBNPBWR1MAPTKDM4E | |
| SCHEMBL10697449 | 0.92 | AURKA (0.57) | AURKAAURKBNPBWR1MAPTKDM4E | |
| SCHEMBL10696033 | 0.79 | PDE4A (0.54) | AURKAAURKBKDM4EALDH1A1GAA | |
| SCHEMBL13341256 | 0.78 | AURKA (0.49) | AURKAAURKBNPBWR1MAPTKDM4E | |
| SCHEMBL10699765 | 0.77 | AURKA (0.48) | AURKAAURKBMAPTKDM4EALDH1A1 | |
| SCHEMBL10694262 | 0.77 | AURKB (0.48) | AURKAAURKBNPBWR1BRD4PDE4A | |
| SCHEMBL10696997 | 0.77 | AURKA (0.48) | AURKAAURKBMAPTKDM4EALDH1A1 | |
| SCHEMBL13367949 | 0.76 | AURKA (0.47) | AURKAAURKBKDM4EALDH1A1BRD4 | |
| SCHEMBL10695470 | 0.76 | MAPT (0.49) | AURKAAURKBMAPTKDM4EALDH1A1 | |
| SCHEMBL10697190 | 0.76 | AURKA (0.54) | AURKAAURKBNPBWR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |