Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696432 | 0.92 | AURKA (0.48) | AURKAAURKBCHEK1SRCCDK2 | |
| SCHEMBL10697347 | 0.90 | AURKA (0.46) | AURKAAURKBNPBWR1BRD4MAPT | |
| SCHEMBL10697190 | 0.83 | AURKA (0.54) | AURKAAURKBCHEK1SRCCDK2 | |
| Hydrochloric Acid SCHEMBL10699432 | 0.79 | AURKA (0.56) | AURKAAURKBCHEK1SRCCDK2 | |
| SCHEMBL10696602 | 0.78 | AURKA (0.60) | AURKAAURKBCHEK1SRCCDK2 | |
| SCHEMBL10700525 | 0.78 | AURKA (0.61) | AURKAAURKBCHEK1SRCCDK2 | |
| SCHEMBL9143168 | 0.77 | AURKA (0.56) | AURKAAURKBNPBWR1MAPTKDM4E | |
| SCHEMBL10698143 | 0.77 | AURKA (0.59) | AURKAAURKBCHEK1SRCCDK2 | |
| SCHEMBL4945475 | 0.77 | AURKA (0.92) | AURKAAURKBCHEK1SRCCDK2 | |
| SCHEMBL10698507 | 0.77 | AURKB (0.59) | AURKAAURKBCHEK1SRCCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |