Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | CYP2E1 | P05181 | 6/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 6/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 6/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9678554 | 0.90 | SMN1; SMN2 (0.58) | SMN1; SMN2PRMT5WDR77CYP2E1CYP2C8 | |
| SCHEMBL10701057 | 0.88 | SMN1; SMN2 (0.54) | SMN1; SMN2PRMT5WDR77CYP2E1CYP2C8 | |
| SCHEMBL10698219 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2PRMT5WDR77MAPTNPC1 | |
| SCHEMBL10699314 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2PRMT5WDR77CYP2E1CYP2C8 | |
| SCHEMBL10710732 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2PRMT5WDR77CYP2E1CYP2C8 | |
| SCHEMBL10699503 | 0.82 | PTGS2 (0.49) | SMN1; SMN2PRMT5WDR77CYP2E1CYP2C8 | |
| SCHEMBL10700126 | 0.81 | SMN1; SMN2 (0.45) | SMN1; SMN2PRMT5WDR77CYP2E1CYP2C8 | |
| SCHEMBL9678318 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2PRMT5WDR77CYP2E1CYP2C8 | |
| SCHEMBL10711880 | 0.81 | CYP2E1 (0.55) | SMN1; SMN2PRMT5WDR77CYP2E1CYP2C8 | |
| SCHEMBL10701393 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2PRMT5CYP2E1CYP2C8CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0251536-A1 | Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors | FISONS plc (GB) | 1988-01-07 | — | — | EP | claimed |
| EP-0251536-A1 | Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors | FISONS plc (GB) | 1988-01-07 | — | — | EP | disclosed |