Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | CYP2E1 | P05181 | 7/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 7/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.47 |
| ▸ | CYP2B6 | P20813 | 7/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699314 | 0.92 | SMN1; SMN2 (0.50) | SMN1; SMN2CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL10710732 | 0.92 | SMN1; SMN2 (0.50) | SMN1; SMN2CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL10701057 | 0.91 | SMN1; SMN2 (0.54) | SMN1; SMN2CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL10697968 | 0.90 | SMN1; SMN2 (0.53) | SMN1; SMN2CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL10699503 | 0.89 | PTGS2 (0.49) | SMN1; SMN2CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL10698219 | 0.87 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTPRMT5WDR77NPC1 | |
| SCHEMBL10700869 | 0.86 | PTGS2 (0.49) | SMN1; SMN2CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL9678318 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL10711880 | 0.85 | CYP2E1 (0.55) | SMN1; SMN2CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL9677090 | 0.84 | HRH4 (0.55) | SMN1; SMN2CYP2E1CYP2C8CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0174717-B1 | BENZIMIDAZOLES, AND THEIR PRODUCTION FORMULATION AND USE AS GASTRIC ACID SECRETION INHIBITORS | FISONS plc (GB) | 1992-01-22 | — | — | EP | disclosed |
| EP-0174717-A1 | Benzimidazoles, and their production formulation and use as gastric acid secretion inhibitors | FISONS plc (GB) | 1986-03-19 | — | — | EP | disclosed |