Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 12/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 11/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9678554 | 0.87 | SMN1; SMN2 (0.58) | SMN1; SMN2PRMT5WDR77LMNARAB9A | |
| SCHEMBL10701057 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2PRMT5WDR77LMNARAB9A | |
| SCHEMBL10697968 | 0.84 | SMN1; SMN2 (0.53) | SMN1; SMN2PRMT5WDR77LMNARAB9A | |
| SCHEMBL9676691 | 0.83 | RAB9A (0.58) | SMN1; SMN2PRMT5WDR77LMNARAB9A | |
| SCHEMBL6475746 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2PRMT5WDR77LMNARAB9A | |
| SCHEMBL10700628 | 0.80 | PRMT5 (0.36) | SMN1; SMN2PRMT5WDR77LMNARAB9A | |
| SCHEMBL10699314 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2PRMT5WDR77RAB9AHTT | |
| SCHEMBL10710732 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2PRMT5WDR77LMNARAB9A | |
| SCHEMBL10699503 | 0.79 | PTGS2 (0.49) | SMN1; SMN2PRMT5WDR77LMNARAB9A | |
| SCHEMBL10700126 | 0.78 | SMN1; SMN2 (0.45) | SMN1; SMN2PRMT5WDR77LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0251536-A1 | Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors | FISONS plc (GB) | 1988-01-07 | — | — | EP | claimed |
| EP-0251536-A1 | Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors | FISONS plc (GB) | 1988-01-07 | — | — | EP | disclosed |