Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.49 |
| ▸ | TACR3 | P29371 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | CYP11A1 | P05108 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31327704 | 0.83 | TACR1 (0.46) | TACR1TACR3TSHRMEN1KMT2A | |
| SCHEMBL28542067 | 0.77 | MAPT (0.38) | TACR1TACR3TSHRMEN1KMT2A | |
| SCHEMBL29976392 | 0.77 | MAPT (0.38) | TACR1TACR3TSHRMEN1KMT2A | |
| SCHEMBL18150842 | 0.74 | MEN1 (0.44) | TACR1TACR3MEN1KMT2ACYP2C9 | |
| SCHEMBL8675184 | 0.72 | TACR1 (0.39) | TACR1TACR3MEN1KMT2ACYP2C9 | |
| SCHEMBL3007339 | 0.72 | CYP2C9 (0.45) | TACR1TACR3TSHRMEN1KMT2A | |
| SCHEMBL17857588 | 0.72 | CYP1A2 (0.43) | TSHRMEN1KMT2ACYP1A2POLB | |
| SCHEMBL11846334 | 0.71 | TSHR (0.44) | TSHRMEN1KMT2ACYP1A2POLB | |
| Glutethimide SCHEMBL113709 | 0.71 | CYP19A1 (0.72) | CYP1A2CYP19A1CYP3A4CYP17A1CYP11A1 | |
| Glutethimide SCHEMBL21119240 | 0.71 | CYP19A1 (0.72) | CYP1A2CYP19A1CYP3A4CYP17A1CYP11A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4129652-A | CHLORPROMAZINE OR THIORIDAZINE AND 5-ETHYL-5-PHENYL-2-PYRROLIDONE OR 1-HYDROXY-3-AMINO-2-PYRROLIDONE OR SALTS | NELSON RESEARCH & DEVELOPMENT COMPANY (US) | 1978-12-12 | — | — | US | claimed |
| US-20250302803-A1 | ARYL-SUBSTITUTED ACETAMIDE AND PYRROLIDIN-2-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SEIZURES | UNIVERSITY OF HOUSTON SYSTEM (US) | 2025-10-02 | — | — | US | disclosed |
| US-12357610-B2 | Aryl-substituted acetamide and pyrrolidin-2-one derivatives and their use for the treatment of seizures | UNIVERSITY OF HOUSTON SYSTEM (US) | 2025-07-15 | — | — | US | disclosed |
| US-20230414566-A1 | ARYL-SUBSTITUTED ACETAMIDE AND PYRROLIDIN-2-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SEIZURES | UNIVERSITY OF HOUSTON SYSTEM (US) | 2023-12-28 | — | — | US | disclosed |
| US-11806333-B2 | Aryl-substituted acetamide and pyrrolidin-2-one derivatives and their use for the treatment of seizures | UNIVERSITY OF HOUSTON SYSTEM (US) | 2023-11-07 | — | — | US | disclosed |
| US-20200360342-A1 | ARYL-SUBSTITUTED ACETAMIDE AND PYRROLIDIN-2-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SEIZURES | UNIVERSITY OF HOUSTON SYSTEM (US) | 2020-11-19 | — | — | US | disclosed |
| EP-2275143-B1 | Conjugates of perphenazine or fluphenazine with carboxylic acids | UNIV RAMOT (IL) | 2012-12-19 | — | — | EP | disclosed |
| US-20120309748-A1 | CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF | BAR-ILAN UNIVERSITY (IL) | 2012-12-06 | — | — | US | disclosed |
| US-8283381-B2 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2012-10-09 | — | — | US | disclosed |
| US-8168628-B2 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2012-05-01 | — | — | US | disclosed |
| EP-1429844-A2 | CONJUGATED ANTI-PSYCHOTIC DRUGS AND USES THEREOF | Ramot at Tel Aviv University Ltd. (IL) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003026563-A9 | CONJUGATED ANTI-PSYCHOTIC DRUGS AND USES THEREOF | UNIV RAMOT (IL) | 2004-04-22 | — | — | WO | disclosed |
| WO-2003026563-A2 | CONJUGATED ANTI-PSYCHOTIC DRUGS AND USES THEREOF | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2003-04-03 | — | — | WO | disclosed |
| US-20020173537-A1 | 2-pyrrolidinone derivatives substituted at position 4 for reducing the extracellular glutamate level | KLINIKUM DER ALBERT-LUDWIGS-UNIVERSITAET (DE) | 2002-11-21 | — | — | US | disclosed |
| US-6384069-B1 | BRAIN DISORDERS CHRONIC PAIN, HYPOGLYCEMIA, HYPOXIA, TRAUMA, ALZHEIMER'S DISEASE, AIDS-ASSOCIATED DEMENTIA, AMYOTROPHIC LATERAL SCLEROSIS, PARKINSON'S DISEASE, AND CHRONIC ALCOHOLISM, COMPRISING ADMINISTERING TO A PATIENT IN NEED A | KLINIKUM DER ALBERT-LUDWIGS-UNIVERSITAET (DE) | 2002-05-07 | — | — | US | disclosed |
| US-5463125-A | 3-hydroxy-3-phenylpentamide | SANDOVAL GUILLERMO C (MX) | 1995-10-31 | — | — | US | disclosed |
| US-4138484-A | CHLORPROMAZINE OR THORIDAZINE WITH G-HYDROXYBUTYROLACTONE | NELSON RESEARCH & DEVELOPMENT COMPANY (US) | 1979-02-06 | — | — | US | disclosed |
| US-4129652-A | CHLORPROMAZINE OR THIORIDAZINE AND 5-ETHYL-5-PHENYL-2-PYRROLIDONE OR 1-HYDROXY-3-AMINO-2-PYRROLIDONE OR SALTS | NELSON RESEARCH & DEVELOPMENT COMPANY (US) | 1978-12-12 | — | — | US | disclosed |
| US-4084000-A | NEUROLEPTIC, GAMMA-AMINOBUTYRIC ACID DERIVATIVES | NELSON RESEARCH AND DEVELOPMENT COMPANY (US) | 1978-04-11 | — | — | US | disclosed |
| US-3978216-A | AMINOOXYACETIC ACID | NELSON RESEARCH & DEVELOPMENT COMPANY (US) | 1976-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200360342-A1 | ARYL-SUBSTITUTED ACETAMIDE AND PYRROLIDIN-2-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SEIZURES | AADAC, GABRB2, GABARAPL2 | TACR1 3742/4885TACR3 3549/4885TSHR 3185/4885 |
| US-12357610-B2 | Aryl-substituted acetamide and pyrrolidin-2-one derivatives and their use for the treatment of seizures | AADAC, GABRB2, GABARAPL2 | TACR1 3742/4885TACR3 3549/4885TSHR 3185/4885 |
| US-20250302803-A1 | ARYL-SUBSTITUTED ACETAMIDE AND PYRROLIDIN-2-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SEIZURES | AADAC, GABRB2, GABARAPL2 | TACR1 3742/4885TACR3 3549/4885TSHR 3185/4885 |
| US-20230414566-A1 | ARYL-SUBSTITUTED ACETAMIDE AND PYRROLIDIN-2-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SEIZURES | AADAC, GABRB2, GABARAPL2 | TACR1 3742/4885TACR3 3549/4885TSHR 3185/4885 |
| US-20020173537-A1 | 2-pyrrolidinone derivatives substituted at position 4 for reducing the extracellular glutamate level | GRM1, GRM2, GRIN2A | TACR1 1656/4885TACR3 4453/4885TSHR 1693/4885 |
| US-11806333-B2 | Aryl-substituted acetamide and pyrrolidin-2-one derivatives and their use for the treatment of seizures | AADAC, GABRB2, GABARAPL2 | TACR1 3742/4885TACR3 3549/4885TSHR 3185/4885 |
| US-20120309748-A1 | CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF | SLC18A2, SLC6A3, SLCO1B3 | TACR1 320/4885TACR3 1438/4885TSHR 2603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.