Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 8/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697943 | 0.94 | MAPT (0.41) | NPC1RAB9AMCL1MAPTKMT2A | |
| SCHEMBL10698960 | 0.94 | MAPT (0.41) | NPC1RAB9AMCL1MAPTKMT2A | |
| SCHEMBL10699997 | 0.89 | MAPT (0.51) | NPC1RAB9AMAPTKMT2ALMNA | |
| SCHEMBL2489397 | 0.89 | KMT2A (0.44) | NPC1RAB9AMAPTKMT2ALMNA | |
| SCHEMBL2485998 | 0.89 | MAPT (0.46) | NPC1RAB9AMAPTKMT2ALMNA | |
| SCHEMBL10693972 | 0.87 | NPC1 (0.41) | NPC1RAB9AMCL1MAPTKMT2A | |
| SCHEMBL10709260 | 0.87 | MAPT (0.49) | NPC1RAB9AMAPTKMT2ALMNA | |
| SCHEMBL10710954 | 0.87 | MAPT (0.39) | NPC1RAB9AMAPTKMT2ALMNA | |
| SCHEMBL10531293 | 0.86 | NPC1 (0.38) | NPC1RAB9AMCL1MAPTKMT2A | |
| SCHEMBL10698512 | 0.86 | MAPT (0.43) | NPC1RAB9AMCL1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4778898-A | CROSSLINKED, HEAT RESISTANT POLYMERS; ADHESIVES, INSULATION, PLASTICS | CIBA-GEIGY CORPORATION (US) | 1988-10-18 | — | — | US | disclosed |
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |