Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697943 | 0.97 | MAPT (0.41) | MAPTKMT2ALMNAMAPK1MEN1 | |
| SCHEMBL10698083 | 0.94 | NPC1 (0.40) | MAPTKMT2ALMNAMAPK1MEN1 | |
| SCHEMBL10701527 | 0.90 | MAPT (0.49) | MAPTKMT2AMAPK1MEN1NPC1 | |
| SCHEMBL10696534 | 0.88 | MAPT (0.42) | MAPTKMT2ALMNAMAPK1MEN1 | |
| SCHEMBL10699942 | 0.88 | MAPT (0.51) | MAPTKMT2ALMNAMAPK1MEN1 | |
| SCHEMBL10699998 | 0.87 | MAPT (0.49) | MAPTKMT2AMAPK1MEN1NPC1 | |
| SCHEMBL10696545 | 0.86 | LMNA (0.38) | MAPTKMT2ALMNAMAPK1MEN1 | |
| SCHEMBL10697744 | 0.85 | MAPT (0.41) | MAPTKMT2ALMNAMEN1NPC1 | |
| SCHEMBL10696183 | 0.85 | MAPT (0.51) | MAPTKMT2ALMNAMAPK1MEN1 | |
| SCHEMBL10693972 | 0.85 | NPC1 (0.41) | MAPTKMT2ALMNAMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |