Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.43 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699123 | 0.88 | MAPT (0.52) | MAPTALDH1A1HSPD1HSPE1NPC1 | |
| SCHEMBL10532565 | 0.87 | PGR (0.44) | MAPTALDH1A1HSD17B10HSPD1HSPE1 | |
| SCHEMBL10698083 | 0.86 | NPC1 (0.40) | MAPTALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL10697943 | 0.85 | MAPT (0.41) | MAPTALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL10711637 | 0.84 | NPC1 (0.48) | MAPTALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL10698960 | 0.84 | MAPT (0.41) | MAPTALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL10693972 | 0.83 | NPC1 (0.41) | MAPTALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL10699685 | 0.81 | NPC1 (0.39) | MAPTALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL2489363 | 0.80 | MAPT (0.50) | MAPTALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL2489367 | 0.80 | MAPT (0.50) | MAPTALDH1A1NPC1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |