Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5491000 | 0.88 | SMN1; SMN2 (0.43) | HTR2CSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL2502213 | 0.81 | HTR2C (0.46) | HTR2CSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL2146179 | 0.81 | HTR2C (0.46) | HTR2CSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL18340933 | 0.81 | HTR2C (0.46) | HTR2CSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL17024449 | 0.80 | SMN1; SMN2 (0.43) | HTR2CSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL9812777 | 0.79 | HTR2C (0.43) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL13435783 | 0.78 | HTT (0.40) | HTR2CSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL9519485 | 0.77 | SMN1; SMN2 (0.40) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL27209980 | 0.76 | CTSL (0.39) | HTR2CSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL29156249 | 0.75 | SMN1; SMN2 (0.46) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0280771-A1 | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives and processes for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-09-07 | — | — | EP | disclosed |