Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519970 | 0.87 | ALDH1A1 (0.38) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2317030 | 0.81 | HTR2C (0.41) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL2356930 | 0.81 | HTR2C (0.41) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL2356933 | 0.81 | HTR2C (0.41) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL10698128 | 0.77 | HTR2C (0.43) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL10520465 | 0.76 | ALDH1A1 (0.37) | — | |
| SCHEMBL18592896 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL10519267 | 0.74 | HTR2C (0.35) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL13567846 | 0.73 | SMN1; SMN2 (0.52) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL25327822 | 0.73 | ENPP2 (0.51) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272456-B1 | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds and processes for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-31 | — | — | EP | disclosed |
| US-4822787-A | 3-pyrrolidinylthio-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid compounds and antimicrobial activity thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0272456-A1 | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds and processes for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-29 | — | — | EP | disclosed |