Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 5/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 5/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 5/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10698582 | 0.87 | CYP1A2 (0.41) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL10700180 | 0.87 | BRD4 (0.36) | BRD4BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL10695102 | 0.86 | KDM4E (0.38) | BRD4BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL10698178 | 0.84 | ALDH1A1 (0.40) | BRD4BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL10699134 | 0.82 | ALDH1A1 (0.38) | BRD4ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL10699549 | 0.80 | BMPR1B (0.41) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL10700488 | 0.79 | BMPR1B (0.37) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL10699175 | 0.78 | AURKA (0.38) | BRD4ALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL10698933 | 0.77 | KMT2A (0.36) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL10699780 | 0.74 | BMPR1B (0.37) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |