Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 5/20 | 0.38 |
| ▸ | BMPR1A | P36894 | 5/20 | 0.38 |
| ▸ | ACVRL1 | P37023 | 5/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10698957 | 0.86 | CYP1A2 (0.44) | ALDH1A1KDM4EHSD17B10BRD4BMPR1B | |
| SCHEMBL10699435 | 0.85 | KMT2A (0.40) | ALDH1A1BRD4BMPR1BBMPR1AACVRL1 | |
| SCHEMBL10698133 | 0.84 | BRD4 (0.36) | ALDH1A1KDM4EHSD17B10BRD4BMPR1B | |
| SCHEMBL10697413 | 0.77 | BMPR1B (0.39) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL10699540 | 0.77 | TNKS2 (0.43) | ALDH1A1KDM4EBMPR1BBMPR1AACVRL1 | |
| SCHEMBL10696613 | 0.76 | AURKA (0.40) | ALDH1A1KDM4EHSD17B10BRD4GAA | |
| SCHEMBL10699106 | 0.76 | ALDH1A1 (0.40) | ALDH1A1KDM4EHSD17B10BRD4GAA | |
| SCHEMBL10698931 | 0.74 | KDM4E (0.41) | ALDH1A1KDM4EBMPR1BBMPR1AACVRL1 | |
| SCHEMBL10698582 | 0.74 | CYP1A2 (0.41) | ALDH1A1KDM4EBMPR1BBMPR1AACVRL1 | |
| SCHEMBL10698710 | 0.73 | KMT2A (0.40) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |