Known targets — ChEMBL curated mechanism
823298382338688239847Rdl1Rdl2Rdl3
The experimentally established mechanism targets of Lindane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 4/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9910 | 0.87 | ALDH1A1 (0.40) | ALDH1A1PDE4ACYP1A2CYP2C19NUDT1 | |
| Ammonia Solution, Strong SCHEMBL28937474 | 0.85 | ALDH1A1 (0.39) | ALDH1A1PDE4ACYP1A2CYP2C19NUDT1 | |
| SCHEMBL11394714 | 0.85 | ALDH1A1 (0.39) | ALDH1A1PDE4ACYP1A2CYP2C19NUDT1 | |
| Hydrochloric Acid SCHEMBL11061003 | 0.85 | ALDH1A1 (0.39) | ALDH1A1PDE4ACYP1A2CYP2C19NUDT1 | |
| Water SCHEMBL14861606 | 0.85 | ALDH1A1 (0.39) | ALDH1A1PDE4ACYP1A2CYP2C19NUDT1 | |
| SCHEMBL25422725 | 0.85 | ALDH1A1 (0.42) | ALDH1A1PDE4ACYP1A2CYP2C19NUDT1 | |
| Methyl Alcohol SCHEMBL28283377 | 0.82 | LMNA (0.39) | ALDH1A1PDE4ACYP1A2CYP2C19NUDT1 | |
| SCHEMBL28299149 | 0.82 | ALDH1A1 (0.38) | ALDH1A1PDE4ACYP1A2CYP2C19NUDT1 | |
| Hydrochloric Acid SCHEMBL11062549 | 0.82 | ALDH1A1 (0.38) | ALDH1A1PDE4ACYP1A2CYP2C19NUDT1 | |
| SCHEMBL10896684 | 0.82 | PDE4A (0.39) | ALDH1A1PDE4ACYP1A2CYP2C19NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102482277-B | Epidermal growth factor receptor inhibitor and the method for treating obstacle | 达纳-法伯癌症研究所有限公司 | 2017-09-19 | — | — | CN | disclosed |
| CN-102482277-A | Egfr inhibitors and methods of treating disorders | DANA FARBER CANCER INST INC | 2012-05-30 | — | — | CN | disclosed |
| EP-0280394-A1 | Phospholipid delivery vehicle for aqueous-insoluble active ingredients | VESTAR, INC. (US) | 1988-08-31 | — | — | EP | disclosed |