Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | KIT | P10721 | 5/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697875 | 0.96 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP1A2KITBMPR1B | |
| SCHEMBL10699542 | 0.90 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP1A2KITBMPR1B | |
| SCHEMBL10698124 | 0.87 | MEN1 (0.44) | CYP11B1CYP11B2CYP1A2KITBMPR1B | |
| SCHEMBL10694299 | 0.87 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP1A2KITBMPR1B | |
| SCHEMBL10698954 | 0.86 | CYP11B1 (0.48) | CYP11B1CYP11B2CYP1A2KITBMPR1B | |
| SCHEMBL10697238 | 0.83 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP1A2KITBMPR1B | |
| SCHEMBL10700170 | 0.82 | BMPR1B (0.38) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL10699129 | 0.80 | NPC1 (0.48) | CYP19A1MEN1KMT2A | |
| SCHEMBL10699071 | 0.78 | BRD4 (0.50) | CYP11B1CYP11B2CYP1A2KITNAMPT | |
| SCHEMBL10698951 | 0.77 | MAPT (0.52) | CYP11B1CYP11B2CYP1A2KITBMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |