Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.39 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700170 | 0.88 | BMPR1B (0.38) | MEN1KMT2ABMPR1BBMPR1AACVRL1 | |
| SCHEMBL10698573 | 0.87 | CYP11B1 (0.50) | MEN1KMT2ABMPR1BBMPR1AACVRL1 | |
| SCHEMBL10695099 | 0.86 | MEN1 (0.48) | MEN1KMT2ABMPR1BBMPR1AACVRL1 | |
| SCHEMBL10697875 | 0.83 | CYP11B1 (0.50) | MEN1KMT2ABMPR1BBMPR1AACVRL1 | |
| SCHEMBL10699753 | 0.81 | KDM4E (0.41) | MEN1KMT2ABMPR1BBMPR1AACVRL1 | |
| SCHEMBL10699129 | 0.81 | NPC1 (0.48) | MEN1KMT2AALDH1A1KDM4ENPC1 | |
| SCHEMBL10700479 | 0.78 | ALDH1A1 (0.46) | MEN1KMT2ABMPR1BBMPR1AACVRL1 | |
| SCHEMBL10699542 | 0.77 | CYP11B1 (0.47) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL10701670 | 0.77 | NPC1 (0.48) | MEN1KMT2AALDH1A1KDM4ENPC1 | |
| SCHEMBL10699166 | 0.76 | BRD4 (0.51) | MEN1KMT2AKITALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |