Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 2/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699610 | 0.89 | MEN1 (0.36) | KDM4EALDH1A1HSD17B10HPGDTDP1 | |
| SCHEMBL10698674 | 0.88 | KDM4E (0.34) | KDM4EALDH1A1HSD17B10ALOX15HPGD | |
| SCHEMBL10699175 | 0.88 | AURKA (0.38) | KDM4EALDH1A1HSD17B10ALOX15HPGD | |
| SCHEMBL10698037 | 0.85 | ALDH1A1 (0.38) | KDM4EALDH1A1HSD17B10ALOX15TDP1 | |
| SCHEMBL10695178 | 0.83 | KDM4E (0.38) | KDM4EALDH1A1HSD17B10ALOX15HPGD | |
| SCHEMBL10699882 | 0.79 | KDM4E (0.35) | KDM4EALDH1A1HSD17B10ALOX15HPGD | |
| SCHEMBL10697525 | 0.78 | MEN1 (0.36) | KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL10697223 | 0.78 | MEN1 (0.38) | KDM4EALDH1A1HPGDTDP1L3MBTL1 | |
| SCHEMBL10700743 | 0.77 | MEN1 (0.33) | KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL10698284 | 0.76 | MEN1 (0.39) | KDM4EALDH1A1HSD17B10HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |