Orthotolidine

Orthotolidine

SCHEMBL1069890

Cc1cc(-c2ccc(N)c(C)c2)ccc1N.Cc1ccccc1.N=C=O.N=C=O

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 5/20 0.59
CYP3A4 P08684 4/20 0.59
ALDH1A1 P00352 4/20 0.59
TSHR P16473 3/20 0.59
SMN1; SMN2 Q16637 3/20 0.41
KDM4E B2RXH2 3/20 0.41
MAPT P10636 3/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
PKM P14618 1/20 0.41
HDAC2 Q92769 2/20 0.40
TP53 P04637 2/20 0.39
MAPK1 P28482 1/20 0.39
ALOX12 P18054 3/20 0.38
LMNA P02545 2/20 0.38
ACHE P22303 1/20 0.38
IKBKB O14920 1/20 0.38
HDAC3 O15379 1/20 0.37
HDAC1 Q13547 1/20 0.37
APP P05067 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Orthotolidine SCHEMBL3410367 0.89 CYP3A4 (0.74) TDP1CYP3A4ALDH1A1TSHRSMN1; SMN2
Orthotolidine SCHEMBL635398 0.89 CYP3A4 (0.74) TDP1CYP3A4ALDH1A1TSHRSMN1; SMN2
Orthotolidine SCHEMBL8061312 0.89 TDP1 (0.74) TDP1CYP3A4ALDH1A1TSHRSMN1; SMN2
Orthotolidine SCHEMBL11207210 0.87 TDP1 (0.71) TDP1CYP3A4ALDH1A1TSHRSMN1; SMN2
SCHEMBL28690517 0.82 TDP1 (0.63) TDP1CYP3A4ALDH1A1TSHRSMN1; SMN2
O-Tolylamine SCHEMBL28417386 0.82 CYP3A4 (0.58) TDP1CYP3A4ALDH1A1TSHRSMN1; SMN2
Orthotolidine SCHEMBL28342351 0.81 TDP1 (0.61) TDP1CYP3A4ALDH1A1TSHRSMN1; SMN2
SCHEMBL807858 0.79 TDP1 (0.77) TDP1CYP3A4ALDH1A1TSHRSMN1; SMN2
SCHEMBL4662602 0.77 CYP3A4 (0.81) TDP1CYP3A4ALDH1A1TSHRSMN1; SMN2
Orthotolidine SCHEMBL49414 0.77 CYP3A4 (1.00) TDP1CYP3A4ALDH1A1TSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2271692-B1 COMPOSITION AND METHOD FOR CORROSION PROTECTION OF A STRUCTURE BOEING CO (US) 2013-07-24 EP disclosed
US-8367791-B2 Composition and method for corrosion protection of a structure THE BOEING COMPANY (US) 2013-02-05 US disclosed
US-20110143145-A1 Composition and Method for Corrosion Protection of a Structure THE BOEING COMPANY (US) 2011-06-16 US disclosed
US-7906215-B2 Composition and method for corrosion protection of a structure THE BOEING COMPANY (US) 2011-03-15 US disclosed
EP-2271692-A2 COMPOSITION AND METHOD FOR CORROSION PROTECTION OF A STRUCTURE The Boeing Company (US) 2011-01-12 EP disclosed
US-20090263664-A1 COMPOSITION AND METHOD FOR CORROSION PROTECTION OF A STRUCTURE THE BOEING COMPANY (US) 2009-10-22 US disclosed
WO-2009129206-A2 COMPOSITION AND METHOD FOR CORROSION PROTECTION OF A STRUCTURE THE BOEING COMPANY (US) 2009-10-22 WO disclosed