Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.71 |
| ▸ | TSHR | P16473 | 4/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orthotolidine SCHEMBL8061312 | 0.98 | TDP1 (0.74) | TDP1ALDH1A1CYP3A4TSHRSMN1; SMN2 | |
| Orthotolidine SCHEMBL1069890 | 0.87 | TDP1 (0.59) | TDP1ALDH1A1CYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL807858 | 0.87 | TDP1 (0.77) | TDP1ALDH1A1CYP3A4TSHRSMN1; SMN2 | |
| Orthotolidine SCHEMBL28067975 | 0.87 | CYP3A4 (0.94) | TDP1ALDH1A1CYP3A4TSHRSMN1; SMN2 | |
| Orthotolidine SCHEMBL6009632 | 0.87 | CYP3A4 (0.94) | TDP1ALDH1A1CYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL4662602 | 0.85 | CYP3A4 (0.81) | TDP1ALDH1A1CYP3A4TSHRSMN1; SMN2 | |
| Orthotolidine SCHEMBL29386552 | 0.84 | CYP3A4 (1.00) | TDP1ALDH1A1CYP3A4TSHRSMN1; SMN2 | |
| Orthotolidine SCHEMBL29365329 | 0.84 | CYP3A4 (1.00) | TDP1ALDH1A1CYP3A4TSHRSMN1; SMN2 | |
| Orthotolidine SCHEMBL49414 | 0.84 | CYP3A4 (1.00) | TDP1ALDH1A1CYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL25261675 | 0.83 | ALDH1A1 (0.71) | TDP1ALDH1A1CYP3A4TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4389510-A | Water soluble polyimide prepared from 1,2,3,4 butane tetracarboxylic acid and method of preparation | UNITED TECHNOLOGIES CORPORATION (US) | 1983-06-21 | — | — | US | disclosed |