Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696515 | 0.95 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL10699652 | 0.94 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL10717276 | 0.93 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL10698508 | 0.88 | MAPT (0.53) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL10698083 | 0.83 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL10703903 | 0.82 | SMN1; SMN2 (0.52) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL2489397 | 0.82 | KMT2A (0.44) | NPC1RAB9AMAPTCYP1A2CYP3A4 | |
| SCHEMBL2485998 | 0.81 | MAPT (0.46) | NPC1RAB9AMAPTCYP1A2CYP2C9 | |
| SCHEMBL10534281 | 0.81 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL10697121 | 0.81 | MEN1 (0.49) | SMN1; SMN2MAPTL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |