Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10698900 | 0.88 | NPC1 (0.52) | MAPTNPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL10717276 | 0.87 | NPC1 (0.53) | MAPTNPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL10696515 | 0.86 | NPC1 (0.50) | MAPTNPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL10699652 | 0.85 | NPC1 (0.49) | MAPTNPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL10693972 | 0.82 | NPC1 (0.41) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL10698788 | 0.78 | MAPT (0.55) | MAPTNPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL10695938 | 0.78 | MAPT (0.52) | MAPTNPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL5563212 | 0.78 | RECQL (0.42) | MAPTCYP3A4L3MBTL1KMT2ALMNA | |
| SCHEMBL10534281 | 0.78 | NPC1 (0.51) | MAPTNPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL10696897 | 0.77 | L3MBTL1 (0.51) | MAPTNPC1RAB9AL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |