Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 10/20 | 0.47 |
| ▸ | PARP1 | P09874 | 6/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 7/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212138 | 0.75 | GPR3 (0.36) | TNKS2PARP1ALOX15PDPK1CA12 | |
| SCHEMBL22207639 | 0.71 | PARP1 (0.39) | PARP1ALOX15SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4275536 | 0.69 | PARP1 (0.53) | TNKS2PARP1TNKSKMT2AALDH1A1 | |
| SCHEMBL2862 | 0.69 | — | — | |
| SCHEMBL2515687 | 0.68 | ELANE (0.46) | TNKS2PARP1ALOX15PDPK1CA12 | |
| SCHEMBL4271583 | 0.68 | IP6K1 (0.33) | PARP1 | |
| SCHEMBL3863519 | 0.67 | KDM4E (0.42) | TNKS2PARP1ALOX15PDPK1CA12 | |
| SCHEMBL554567 | 0.67 | ALDH1A1 (0.40) | TNKS2PARP1CA12SMN1; SMN2CA9 | |
| SCHEMBL1357471 | 0.65 | DYRK1A (0.46) | PARP1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL383127 | 0.64 | KMT2A (0.44) | TNKS2PARP1PDPK1TNKSKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4262 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4271674-A1 | CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2023-11-08 | — | — | EP | claimed |
| EP-3424926-A1 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINS, THEIR PRODUCTION AND UTILISATION AS MEDICINE | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2019-01-09 | — | — | EP | claimed |
| EP-2943481-B1 | (HETERO)ARYLACETAMIDE DERIVATIVES AS ANTIRETROVIRAL AGENTS | GILEAD SCIENCES INC (US) | 2018-05-02 | — | — | EP | claimed |
| EP-3027601-B1 | SYK INHIBITORS | GILEAD SCIENCES INC (US) | 2017-10-25 | — | — | EP | claimed |
| EP-2350068-B1 | UREA DERIVATIVES OF SUBSTITUTED NORTROPANES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE | BOEHRINGER INGELHEIM INT (DE) | 2017-08-30 | — | — | EP | claimed |
| US-20170166560-A1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-06-15 | — | — | US | claimed |
| EP-1773786-B1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | claimed |
| US-20160368918-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2016-12-22 | — | — | US | claimed |
| US-9376441-B2 | Substituted pyrrolidines as SYK inhibitors | GILEAD SCIENCES, INC. (US) | 2016-06-28 | — | — | US | claimed |
| EP-3027601-A1 | SYK INHIBITORS | Gilead Sciences, Inc. (US) | 2016-06-08 | — | — | EP | claimed |
| US-20030186988-A1 | Thiazol-2-yl-imine compounds as PDE-7 inhibitors | WARNER-LAMBERT COMPANY LLC | 2003-10-02 | — | — | US | claimed |
| EP-1348433-A1 | Thiazol-2-yl-imine compounds as PDE-7 inhibitors | Warner-Lambert Company LLC (US) | 2003-10-01 | — | — | EP | claimed |
| EP-1348701-A1 | (2,4-disubstituted-thiazol-5-yl) amine compounds as PDE7 inhibitors | Warner-Lambert Company LLC (US) | 2003-10-01 | — | — | EP | claimed |
| WO-2003032916-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | STRUCTURAL BIOINFORMATICS INC. (US) | 2003-04-24 | — | — | WO | claimed |
| US-20030013847-A1 | Cytoprotective agents | MONSANTO TECHNOLOGY LLC | 2003-01-16 | — | — | US | claimed |
| WO-2002090314-A1 | PYRUVATE DERIVATIVES | GALILEO LABORATORIES, INC. (US) | 2002-11-14 | — | — | WO | claimed |
| EP-0299694-B1 | Acrylate fungicides | AVENTIS CROPSCIENCE UK LTD (GB) | 2000-10-11 | — | — | EP | claimed |
| US-5801181-A | Amino alcohol substituted cyclic compounds | CELL THERAPEUTICS, INC. (US) | 1998-09-01 | — | — | US | claimed |
| EP-0254627-B1 | DERIVATIVES OF BENZHYDRYLOXYETHYLPIPERAZINE, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Société anonyme: LES LABORATOIRES MERAM (FR) | 1992-06-17 | — | — | EP | claimed |
| EP-0254627-A1 | Derivatives of benzhydryloxyethylpiperazine, processes for their preparation and pharmaceutical compositions containing them | Société anonyme: LES LABORATOIRES MERAM (FR) | 1988-01-27 | — | — | EP | claimed |