Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6481712 | 0.91 | CYP1A2 (0.35) | CYP1A2CYP2C19CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL10713992 | 0.87 | CACNA1D (0.36) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL10699957 | 0.87 | LMNA (0.37) | CYP1A2CYP2C19CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL6481789 | 0.87 | ATP4A (0.36) | CYP1A2CYP2C19CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL6480755 | 0.85 | PRMT5 (0.38) | CYP1A2CYP2C19CYP2E1CYP2C8CYP2D6 | |
| SCHEMBL9675877 | 0.85 | HDAC6 (0.41) | CYP1A2CYP2C19CYP2D6LMNA | |
| SCHEMBL10712255 | 0.84 | ALDH1A1 (0.34) | CYP1A2CYP2C19CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL9395810 | 0.83 | ATP4A (0.43) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL6481718 | 0.82 | LMNA (0.43) | CYP1A2CYP2C19CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL10711681 | 0.82 | CACNA1D (0.36) | MAPTMEN1ALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0251536-A1 | Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors | FISONS plc (GB) | 1988-01-07 | — | — | EP | claimed |
| EP-0251536-A1 | Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors | FISONS plc (GB) | 1988-01-07 | — | — | EP | disclosed |