Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | CASR | P41180 | 4/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL10701912 | 1.00 | KIF11 (0.38) | KIF11ALDH1A1KDM4ELMNAMAPT | |
| Histidine SCHEMBL27960814 | 0.90 | SLC7A5 (0.43) | KDM4ELMNAMAPTSMN1; SMN2CYP2D6 | |
| Histidine SCHEMBL16879773 | 0.85 | SLC7A5 (0.45) | KIF11KDM4ELMNAMAPTSLC1A3 | |
| Histidine SCHEMBL27702203 | 0.85 | SLC7A5 (0.45) | KIF11KDM4ELMNAMAPTSLC1A3 | |
| Histidine SCHEMBL17874426 | 0.85 | SLC7A5 (0.41) | ALDH1A1KDM4ELMNAMAPTCYP2D6 | |
| Histidine SCHEMBL17874427 | 0.85 | SLC7A5 (0.41) | ALDH1A1KDM4ELMNAMAPTCYP2D6 | |
| Histidine SCHEMBL503856 | 0.85 | SLC7A5 (0.43) | ALDH1A1KDM4ELMNAMAPTTDP1 | |
| Histidine SCHEMBL503857 | 0.85 | SLC7A5 (0.43) | ALDH1A1KDM4ELMNAMAPTTDP1 | |
| SCHEMBL7280864 | 0.84 | LMNA (0.43) | ALDH1A1KDM4ELMNAMAPTTDP1 | |
| SCHEMBL7353357 | 0.84 | LMNA (0.43) | ALDH1A1KDM4ELMNAMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119100641-A | Anticorrosive concrete additive and preparation method thereof | 咸宁职业技术学院 | 2024-12-10 | — | — | CN | claimed |
| EP-0154581-B1 | ALPHA-CHLORINATED CARBONATES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION TO THE PROTECTION OF AMINIC FUNCTIONS IN AMINO ACIDS | SOCIETE NATIONALE DES POUDRES ET EXPLOSIFS (FR) | 1988-06-08 | — | — | EP | claimed |
| CN-119100641-A | Anticorrosive concrete additive and preparation method thereof | 咸宁职业技术学院 | 2024-12-10 | — | — | CN | disclosed |
| CN-116408286-A | Size exclusion chromatographic column cleaning agent and cleaning method | 广州百济神州生物制药有限公司 | 2023-07-11 | — | — | CN | disclosed |
| CN-112798720-B | Application of histidine buffer solution in reduction of protein aggregates | 苏州药明生物技术有限公司 | 2022-04-19 | — | — | CN | disclosed |
| CN-112798720-A | Application of histidine buffer solution in reduction of protein aggregates | 苏桥生物(苏州)有限公司 | 2021-05-14 | — | — | CN | disclosed |