Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.55 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10739815 | 0.90 | GPR119 (0.60) | PDE3BPDE3AGPR119 | |
| SCHEMBL10704316 | 0.87 | PDE3B (0.50) | PDE3BPDE3AGPR119XDH | |
| SCHEMBL10703474 | 0.86 | PDE3B (0.55) | PDE3BPDE3AGPR119 | |
| SCHEMBL10840969 | 0.85 | PDE3B (0.57) | PDE3BPDE3AGPR119 | |
| SCHEMBL10839094 | 0.83 | PDE3B (0.48) | PDE3BPDE3AGPR119XDH | |
| SCHEMBL10704539 | 0.82 | PDE3B (0.68) | PDE3BPDE3AGPR119 | |
| SCHEMBL10704549 | 0.82 | PDE3B (0.51) | PDE3BPDE3AGPR119 | |
| SCHEMBL10763921 | 0.76 | PDE3B (0.71) | PDE3BPDE3AGPR119XDHTBK1 | |
| SCHEMBL11097309 | 0.75 | GPR119 (0.46) | PDE3BPDE3AGPR119 | |
| SCHEMBL7266588 | 0.74 | GPR119 (0.59) | PDE3BPDE3AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0172141-B1 | SUBSTITUTED PYRIDAZINONES, METHOD FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATION CONTAINING THESE COMPOUNDS AND THEIR USE | CIBA-GEIGY AG (CH) | 1988-12-07 | — | — | EP | claimed |
| US-4624951-A | Substituted pyridazinones, pharmaceutical preparations containing these compounds, and the use thereof | CIBA-GEIGY CORPORATION (US) | 1986-11-25 | — | — | US | claimed |
| EP-0172141-A1 | Substituted pyridazinones, method for their preparation, pharmaceutical preparation containing these compounds and their use | CIBA-GEIGY AG (CH) | 1986-02-19 | — | — | EP | claimed |
| EP-0172141-B1 | SUBSTITUTED PYRIDAZINONES, METHOD FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATION CONTAINING THESE COMPOUNDS AND THEIR USE | CIBA-GEIGY AG (CH) | 1988-12-07 | — | — | EP | disclosed |
| US-4624951-A | Substituted pyridazinones, pharmaceutical preparations containing these compounds, and the use thereof | CIBA-GEIGY CORPORATION (US) | 1986-11-25 | — | — | US | disclosed |
| EP-0172141-A1 | Substituted pyridazinones, method for their preparation, pharmaceutical preparation containing these compounds and their use | CIBA-GEIGY AG (CH) | 1986-02-19 | — | — | EP | disclosed |