Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.44 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11013347 | 0.82 | PDE3B (0.45) | GPR119PDE3BPDE3ATNNC1PDE2A | |
| SCHEMBL10956557 | 0.82 | PDE3B (0.48) | GPR119PDE3BPDE3ATNNC1PDE2A | |
| SCHEMBL11625496 | 0.79 | GPR119 (0.66) | GPR119PDE3BPDE3ATNNC1KDM4E | |
| SCHEMBL10961794 | 0.78 | GPR119 (0.54) | GPR119PDE3BPDE3ATNNC1PDE2A | |
| SCHEMBL10961439 | 0.78 | PDE3B (0.46) | GPR119PDE3BPDE3ATNNC1PDE2A | |
| SCHEMBL10959297 | 0.76 | GPR119 (0.48) | GPR119PDE3BPDE3APDE2AHRH3 | |
| SCHEMBL10961657 | 0.75 | PDE3B (0.45) | GPR119PDE3BPDE3APDE2AKDM4E | |
| SCHEMBL11046458 | 0.75 | PDE3B (0.71) | PDE3BPDE3ATNNC1PDE2AKDM4E | |
| SCHEMBL10703150 | 0.75 | PDE3B (0.55) | GPR119PDE3BPDE3A | |
| SCHEMBL10704539 | 0.74 | PDE3B (0.68) | GPR119PDE3BPDE3APDE2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129791-A2 | Tetrahydropyridazinone derivatives, process for their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1985-01-02 | — | — | EP | disclosed |