Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.60 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.55 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10703150 | 0.90 | PDE3B (0.55) | GPR119PDE3BPDE3A | |
| SCHEMBL10704316 | 0.87 | PDE3B (0.50) | GPR119PDE3BPDE3A | |
| SCHEMBL10839094 | 0.83 | PDE3B (0.48) | GPR119PDE3BPDE3A | |
| SCHEMBL10763921 | 0.76 | PDE3B (0.71) | GPR119PDE3BPDE3A | |
| SCHEMBL10703474 | 0.76 | PDE3B (0.55) | GPR119PDE3BPDE3A | |
| SCHEMBL2588993 | 0.75 | GPR119 (1.00) | GPR119 | |
| SCHEMBL10840969 | 0.75 | PDE3B (0.57) | GPR119PDE3BPDE3A | |
| SCHEMBL7266588 | 0.74 | GPR119 (0.59) | GPR119PDE3BPDE3A | |
| SCHEMBL10704549 | 0.72 | PDE3B (0.51) | GPR119PDE3BPDE3A | |
| SCHEMBL7274554 | 0.72 | GPR119 (0.65) | GPR119PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0180542-A2 | Alkyl substituted pyridazinones, processes for producing them, pharmaceutical preparations containing these compounds, and the use thereof | CIBA-GEIGY AG (CH) | 1986-05-07 | — | — | EP | claimed |
| US-4699908-A | Alkyl substituted pyridazinones and pharmaceutical compositions | CIBA-GEIGY CORPORATION (US) | 1987-10-13 | — | — | US | disclosed |
| US-4629789-A | Alkyl substituted pyridazinones and pharmaceutical compositions | CIBA-GEIGY CORPORATION (US) | 1986-12-16 | — | — | US | disclosed |
| EP-0180542-A2 | Alkyl substituted pyridazinones, processes for producing them, pharmaceutical preparations containing these compounds, and the use thereof | CIBA-GEIGY AG (CH) | 1986-05-07 | — | — | EP | disclosed |