Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.61 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.61 |
| ▸ | CCNC | P24863 | 2/20 | 0.60 |
| ▸ | CDK8 | P49336 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | PDE4A | P27815 | 2/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.57 |
| ▸ | PDE5A | O76074 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10704473 | 0.87 | CCNC (0.67) | PDE3BPDE3AAURKBINCENPCCNC | |
| SCHEMBL7276070 | 0.86 | PDE3B (0.61) | PDE3BPDE3AAURKBINCENPCCNC | |
| SCHEMBL11232569 | 0.84 | CYP46A1 (0.58) | PDE3BPDE3AAURKBINCENPCCNC | |
| SCHEMBL11236769 | 0.84 | KDM4E (0.50) | PDE3BPDE3AAURKBINCENPCCNC | |
| SCHEMBL24334610 | 0.84 | PDE3B (0.60) | PDE3BPDE3AAURKBINCENPCCNC | |
| SCHEMBL16115893 | 0.83 | CCNC (0.74) | PDE3BPDE3AAURKBINCENPCCNC | |
| SCHEMBL11242636 | 0.82 | CDK5 (0.62) | PDE3BPDE3AAURKBINCENPCCNC | |
| SCHEMBL11231155 | 0.81 | HSD17B1 (0.44) | PDE3BPDE3AAURKBINCENPCCNC | |
| SCHEMBL11230843 | 0.81 | PDE3B (0.57) | PDE3BPDE3AAURKBINCENPCCNC | |
| SCHEMBL11238710 | 0.81 | CDK5 (0.49) | PDE3BPDE3AAURKBINCENPCCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4312875-A | 5-(Pyridinyl)-6-(lower-alkyl)-2(1H)-pyridinones, 1,2-dihydro-2-oxo-5-(pyridinyl)-6-(lower-alkyl)nicotinic acids and lower-alkyl esters thereof, and cardiotonic use thereof | STERLING DRUG INC. (US) | 1982-01-26 | — | — | US | claimed |
| US-4312875-A | 5-(Pyridinyl)-6-(lower-alkyl)-2(1H)-pyridinones, 1,2-dihydro-2-oxo-5-(pyridinyl)-6-(lower-alkyl)nicotinic acids and lower-alkyl esters thereof, and cardiotonic use thereof | STERLING DRUG INC. (US) | 1982-01-26 | — | — | US | disclosed |
| US-4309537-A | Production of imidazo[4,5-b]pyridin-2-ones or thiones | STERLING DRUG INC. (US) | 1982-01-05 | — | — | US | disclosed |
| US-4297360-A | 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-27 | — | — | US | disclosed |
| US-4294837-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |
| US-4276293-A | Compositions and their preparation | STERLING DRUG INC. (US) | 1981-06-30 | — | — | US | disclosed |
| US-4265895-A | 1,2-Dihydro-5-pyridinyl-3H-pyrazolo[3,4-b]pyridin-3-ones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-05-05 | — | — | US | disclosed |
| US-4264612-A | Lower-alkyl 2-halo-5-(pyridinyl)nicotinates, their preparation and use as cardiotonics | STERLING DRUG INC. (US) | 1981-04-28 | — | — | US | disclosed |