Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 8/20 | 0.55 |
| ▸ | REN | P00797 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PEPD | P12955 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950273 | 0.82 | ACE (0.58) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL11301917 | 0.82 | ACE (0.73) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL3045658 | 0.81 | ACE (0.68) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL17323620 | 0.81 | ACE (0.68) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL967588 | 0.81 | ACE (0.68) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL8023712 | 0.81 | ACE (0.58) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL6947053 | 0.81 | ACE (0.58) | ACERENLMNAHSD17B10KDM4E | |
| Hydrochloric Acid SCHEMBL6026723 | 0.80 | ACE (0.66) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL9422545 | 0.80 | ACE (0.57) | ACERENLMNAHSD17B10KDM4E | |
| SCHEMBL11370643 | 0.79 | ACE (0.56) | ACERENLMNAHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0038541-B1 | NOVEL PRODRUGS OF BIOLOGICALLY ACTIVE AGENTS CONTAINING MERCAPTO GROUPS, PROCESS FOR PREPARING AND THERAPEUTICALLY EFFECTIVE COMPOSITION CONTAINING THE SAME | MERCK & CO. INC. (US) | 1986-08-13 | — | — | EP | claimed |
| EP-0038541-A1 | Novel prodrugs of biologically active agents containing mercapto groups, process for preparing and therapeutically effective composition containing the same | MERCK & CO. INC. (US) | 1981-10-28 | — | — | EP | claimed |
| EP-0128249-B1 | ANTIMICROBIAL DISULFIDE PRODRUGS | SMITHKLINE BECKMAN CORPORATION (US) | 1988-08-03 | — | — | EP | disclosed |
| EP-0038541-B1 | NOVEL PRODRUGS OF BIOLOGICALLY ACTIVE AGENTS CONTAINING MERCAPTO GROUPS, PROCESS FOR PREPARING AND THERAPEUTICALLY EFFECTIVE COMPOSITION CONTAINING THE SAME | MERCK & CO. INC. (US) | 1986-08-13 | — | — | EP | disclosed |
| US-4443435-A | ANTICARCINOGENS, HYPOTENSIVE AGENTS, HYPERTHYROIDISM | MERCK & CO., INC. (US) | 1984-04-17 | — | — | US | disclosed |
| US-4427582-A | Antimicrobial disulfide prodrugs | SMITHKLINE BECKMAN CORPORATION (US) | 1984-01-24 | — | — | US | disclosed |