Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.73 |
| ▸ | REN | P00797 | 4/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | F2 | P00734 | 1/20 | 0.73 |
| ▸ | LTA4H | P09960 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | PEPD | P12955 | 1/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.73 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.73 |
| ▸ | HTR2A | P28223 | 1/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.73 |
| ▸ | HRH1 | P35367 | 1/20 | 0.73 |
| ▸ | THPO | P40225 | 1/20 | 0.73 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.73 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950273 | 0.85 | ACE (0.58) | ACERENLMNAHSD17B10KDM4E | |
| D-Captopril SCHEMBL678794 | 0.84 | ACE (1.00) | ACERENLMNAHSD17B10KDM4E | |
| D-Captopril SCHEMBL675797 | 0.84 | ACE (1.00) | ACERENLMNAHSD17B10KDM4E | |
| D-Captopril SCHEMBL2444049 | 0.84 | ACE (1.00) | ACERENLMNAHSD17B10KDM4E | |
| D-Captopril SCHEMBL7983782 | 0.84 | ACE (1.00) | ACERENLMNAHSD17B10KDM4E | |
| D-Captopril SCHEMBL2444053 | 0.84 | ACE (1.00) | ACERENLMNAHSD17B10KDM4E | |
| Captopril SCHEMBL2786691 | 0.84 | ACE (1.00) | ACERENLMNAHSD17B10KDM4E | |
| Captopril SCHEMBL4 | 0.84 | ACE (1.00) | ACERENLMNAHSD17B10KDM4E | |
| D-Captopril SCHEMBL1913521 | 0.84 | ACE (1.00) | ACERENLMNAHSD17B10KDM4E | |
| D-Captopril SCHEMBL2422871 | 0.84 | ACE (1.00) | ACERENLMNAHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-56068664-A | — | — | None | — | — | JP | disclosed |
| JP-S5668664-A | THIOAMIDE DERIVATIVE | YOSHITOMI PHARMACEUT IND LTD | 1981-06-09 | — | — | JP | disclosed |
| US-4228077-A | N-[2-(mercaptoalkyl)-3-mercaptoalkanoyl]-l-tryptophanes | E. R. SQUIBB & SONS, INC. (US) | 1980-10-14 | — | — | US | disclosed |
| US-4206121-A | ANGIOTENSIN, ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1980-06-03 | — | — | US | disclosed |
| US-4178291-A | HYPOTENSIVE AGENTS, ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-12-11 | — | — | US | disclosed |
| US-4176235-A | ANGIOTENSIN COVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-11-27 | — | — | US | disclosed |
| US-4175199-A | Substituted acyl derivatives of amino acids | E. R. SQUIBB & SONS, INC. (US) | 1979-11-20 | — | — | US | disclosed |
| US-4154936-A | ENZYME INHIBITORS, HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4140864-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-02-20 | — | — | US | disclosed |
| US-4116962-A | ANGIOTENSIN CONVERTING ENXYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1978-09-26 | — | — | US | disclosed |