Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | PTPRB | P23467 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261134 | 0.79 | GPR119 (0.46) | GPR119KDM4EPKMLIMK2USP30 | |
| SCHEMBL391565 | 0.78 | TBK1 (0.45) | GPR119KDM4EPKMLIMK2TBK1 | |
| SCHEMBL5889155 | 0.77 | GPR119 (0.53) | GPR119TGFBR1TBK1 | |
| SCHEMBL4263363 | 0.77 | GPR119 (0.51) | GPR119KDM4EPKMLIMK2TBK1 | |
| SCHEMBL390256 | 0.77 | GPR119 (0.46) | GPR119KDM4EPKMLIMK2TBK1 | |
| SCHEMBL391077 | 0.76 | TBK1 (0.47) | GPR119KDM4EPKMLIMK2TGFBR1 | |
| SCHEMBL1070548 | 0.76 | TBK1 (0.44) | GPR119KDM4EPKMLIMK2TGFBR1 | |
| SCHEMBL391299 | 0.75 | GPR119 (0.46) | GPR119KDM4EPKMLIMK2MEN1 | |
| SCHEMBL27747830 | 0.75 | GPR119 (0.49) | GPR119LIMK2TGFBR1TBK1 | |
| SCHEMBL391649 | 0.74 | GPR119 (0.46) | GPR119KDM4EPKMLIMK2TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004157-B1 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | ARENA PHARM INC (US) | 2011-01-12 | — | — | EP | disclosed |