Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SI | P14410 | 1/20 | 0.30 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2787103 | 0.83 | LMNA (0.50) | LMNAHCAR2SMN1; SMN2MGAMGAA | |
| Methylglyoxal SCHEMBL9148515 | 0.80 | LMNA (0.57) | LMNA | |
| Glyoxylate SCHEMBL5793604 | 0.80 | LMNA (0.57) | LMNAHCAR2 | |
| Formic Acid SCHEMBL6366884 | 0.77 | LMNA (0.67) | LMNA | |
| Glyoxylate SCHEMBL10883513 | 0.77 | LMNA (0.52) | LMNA | |
| SCHEMBL132857 | 0.76 | — | — | |
| SCHEMBL28209142 | 0.76 | MGAM (0.37) | LMNAHCAR2KEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL10607380 | 0.76 | LMNA (0.41) | LMNASMN1; SMN2 | |
| SCHEMBL10626200 | 0.76 | ATM (0.53) | LMNAHCAR2SMN1; SMN2 | |
| Bicarbonate SCHEMBL5374586 | 0.74 | LMNA (0.71) | LMNAMGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0103945-B1 | SUBSTITUTED BENZENEDIOLS AND BENZODIOXINS | THE UPJOHN COMPANY (US) | 1988-04-20 | — | — | EP | claimed |
| US-4501892-A | Pyridyl benzenediols | THE UPJOHN COMPANY (US) | 1985-02-26 | — | — | US | claimed |
| EP-0103945-A2 | Substituted benzenediols and benzodioxins | THE UPJOHN COMPANY (US) | 1984-03-28 | — | — | EP | claimed |
| EP-0103945-B1 | SUBSTITUTED BENZENEDIOLS AND BENZODIOXINS | THE UPJOHN COMPANY (US) | 1988-04-20 | — | — | EP | disclosed |
| US-4501892-A | Pyridyl benzenediols | THE UPJOHN COMPANY (US) | 1985-02-26 | — | — | US | disclosed |
| EP-0103945-A2 | Substituted benzenediols and benzodioxins | THE UPJOHN COMPANY (US) | 1984-03-28 | — | — | EP | disclosed |