SCHEMBL10708945

SCHEMBL10708945

COC(=O)C(O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C(CC(=O)C1CNCCO1)Cc1cccc2ccccc12

nearest known ligand 0.45

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ REN P00797 20/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10708990 0.90 REN (0.38) REN
SCHEMBL9740281 0.88 REN (0.43) REN
SCHEMBL10421591 0.85 REN (0.56) REN
SCHEMBL10712236 0.85 REN (0.42) REN
SCHEMBL10711608 0.84 REN (0.41) REN
SCHEMBL10422706 0.84 REN (0.48) REN
SCHEMBL10709088 0.84 REN (0.46) REN
SCHEMBL10421139 0.83 REN (0.52) REN
SCHEMBL10421552 0.80 REN (0.56) REN
SCHEMBL10617776 0.80 REN (0.55) REN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0281316-A2 Renin inhibitors YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1988-09-07 — — EP disclosed
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