Hydrochloric Acid

Hydrochloric Acid

SCHEMBL1071013

[Cl-].[Cl-].[Cl-].[Cr+3].c1ccc(CN2CN(Cc3ccccc3)CN(Cc3ccccc3)C2)cc1

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 1/20 0.50
SIGMAR1 Q99720 4/20 0.65
ALDH1A1 P00352 1/20 0.55
TDP1 Q9NUW8 1/20 0.55
MC4R P32245 1/20 0.54
DRD4 P21917 1/20 0.52
LMNA P02545 1/20 0.52
POLB P06746 1/20 0.52
FUCA1 P04066 2/20 0.50
CYP3A4 P08684 1/20 0.48
HSD17B10 Q99714 1/20 0.48
CCR3 P51677 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1639911 0.95 SIGMAR1 (0.71) SIGMAR1ALDH1A1TDP1MC4RDRD4
SCHEMBL4448723 0.92 SIGMAR1 (0.68) SIGMAR1ALDH1A1TDP1MC4RDRD4
SCHEMBL301699 0.85 SIGMAR1 (0.81) SIGMAR1MC4RDRD4LMNAPOLB
Hydrochloric Acid SCHEMBL6395057 0.85 MC4R (0.60) SIGMAR1ALDH1A1TDP1MC4RDRD4
SCHEMBL11053834 0.81 SIGMAR1 (0.67) SIGMAR1ALDH1A1MC4RDRD4LMNA
SCHEMBL28100068 0.79 SIGMAR1 (0.59) SIGMAR1ALDH1A1TDP1MC4RDRD4
SCHEMBL6400259 0.79 MC4R (0.64) SIGMAR1ALDH1A1TDP1MC4RDRD4
SCHEMBL8188324 0.79 SIGMAR1 (1.00) SIGMAR1MC4RDRD4LMNAPOLB
SCHEMBL1415730 0.79 SIGMAR1 (1.00) SIGMAR1MC4RDRD4LMNAPOLB
SCHEMBL1041303 0.79 SIGMAR1 (1.00) SIGMAR1MC4RDRD4LMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7579416-B2 Catalyst system for olefin polymerization BASELL POLYOLEFINE GMBH (DE) 2009-08-25 US claimed
US-20060166813-A1 Preparation of supported catalyst systems BASELL POLYOLEFINE GMBH (DE) 2006-07-27 US claimed
EP-1824888-B1 MONOCYCLOPENTADIENYL COMPLEXES BASELL POLYOLEFINE GMBH (DE) 2017-01-18 EP disclosed
EP-1740626-B1 CATALYST SYSTEM FOR OLEFIN POLYMERIZATION, ITS PRODUCTION AND USE BASELL POLYOLEFINE GMBH (DE) 2014-10-22 EP disclosed
US-7973114-B2 Monocyclopentadienyl complexes BASELL POLYOLEFINE GMBH (DE) 2011-07-05 US disclosed
EP-1861409-B1 MONOCYCLOPENTADIENYL COMPLEXES BASELL POLYOLEFINE GMBH (DE) 2011-01-19 EP disclosed
US-7834107-B2 Preparation of polyolefins having high molecular weights in the presence of an organic transition metal compound in a gas-phase fluidized-bed reactor BASELL POLYOLEFINE GMBH (DE) 2010-11-16 US disclosed
US-7795167-B2 Cyclopentadienyl complexes of group 6 substituted by silyl halides BASELL POLYOLEFINE GMBH (DE) 2010-09-14 US disclosed
US-7776980-B2 Monocyclopentadienyl complexes BASELL POLYOLEFINE GMBH (DE) 2010-08-17 US disclosed
EP-1572359-B1 MONOCYCLOPENTADIENYL COMPLEXES BASELL POLYOLEFINE GMBH (DE) 2010-04-28 EP disclosed
EP-1569968-B1 PREPARATION OF CATALYST COMPOSITIONS HAVING IMPROVED ACTIVITY BASELL POLYOLEFINE GMBH (DE) 2010-03-17 EP disclosed
EP-1456248-A1 CATALYST SOLID COMPRISING PYROGENIC SILICA FOR OLEFIN POLYMERIZATION Basell Polyolefine GmbH (DE) 2004-09-15 EP disclosed
WO-2004056481-A1 MONOCYCLOPENTADIENYL COMPLEXES BASELL POLYOLEFINE GMBH (DE) 2004-07-08 WO disclosed
WO-2004056482-A1 MONOCYCLOPENTADIENYL COMPLEXES BASELL POLYOLEFINE GMBH (DE) 2004-07-08 WO disclosed
WO-2004041871-A1 PREPARATION OF CATALYST COMPOSITIONS HAVING IMPROVED ACTIVITY BASELL POLYOLEFINE GMBH (DE) 2004-05-21 WO disclosed
WO-2004020479-A2 MONOCYCLOPENTADIENYL COMPLEXES BASELL POLYOLEFINE GMBH (DE) 2004-03-11 WO disclosed
WO-2004018489-A1 MONOCYCLOPENTADIENYL COMPLEXES BASELL POLYOLEFINE GMBH (DE) 2004-03-04 WO disclosed
US-20040033890-A1 Catalyst system for carrying out olefin polymerization comprising a calcined hydro-talcite serving as a supporting material LYONDELL CHEMICAL TECHNOLOGY, L.P. 2004-02-19 US disclosed
US-20030176275-A1 Catalytic solid supported on calcined hydrotalcite for olefinic polymerisation BASELL POLYOLEFINE GMBH (DE) 2003-09-18 US disclosed
WO-2003054027-A1 CATALYST SOLID COMPRISING PYROGENIC SILICA FOR OLEFIN POLYMERIZATION BASELL POLYOLEFINE GMBH (DE) 2003-07-03 WO disclosed