Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10714481 | 0.77 | TDP2 (0.53) | TDP2AHR | |
| SCHEMBL10711495 | 0.71 | TDP2 (0.49) | TDP2CCNB2CDK1CCNB1GSK3B | |
| SCHEMBL10712267 | 0.69 | TDP2 (0.58) | TDP2GSK3BCDK5AHRPDE3B | |
| SCHEMBL10714905 | 0.68 | TDP2 (0.52) | TDP2AHRPDE3BPDE3ACYP3A4 | |
| SCHEMBL10711419 | 0.68 | TDP2 (0.52) | TDP2AHRCYP3A4GRIA2CYP1A2 | |
| SCHEMBL10713971 | 0.68 | AHR (0.44) | TDP2DRD2DRD4DRD3CCNB2 | |
| SCHEMBL10711508 | 0.68 | TDP2 (0.43) | TDP2CCNB2CDK1CCNB1GSK3B | |
| SCHEMBL18010825 | 0.66 | TDP2 (1.00) | TDP2 | |
| SCHEMBL3409219 | 0.65 | TDP1 (0.39) | TDP2GSK3BCHEK1CYP3A4ALDH1A1 | |
| SCHEMBL21373 | 0.64 | TDP1 (0.48) | TDP2CYP3A4ALDH1A1TP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670566-A | ANTIIFLAMMATORY AGENTS, ANTICOAGULANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-06-02 | — | — | US | disclosed |
| US-4440785-A | Methods of using 2-aminobiphenylacetic acids, esters, and metal salts thereof to treat inflammation | A. H. ROBINS COMPANY, INC. (US) | 1984-04-03 | — | — | US | disclosed |