Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL938200 | 0.83 | RAB9A (0.47) | BACE1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4815057 | 0.81 | BACE1 (0.48) | BACE1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4619778 | 0.81 | BACE1 (0.48) | BACE1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4813819 | 0.81 | BACE1 (0.67) | BACE1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL11656026 | 0.75 | NPC1 (0.47) | NPC1RAB9AMAPTSMN1; SMN2HPGD | |
| SCHEMBL11261390 | 0.74 | NPC1 (0.46) | BACE1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6516769 | 0.72 | RAB9A (0.45) | BACE1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4811686 | 0.72 | BACE1 (0.55) | BACE1GAAPTGDR2 | |
| SCHEMBL11496898 | 0.71 | AKR1B1 (0.48) | BACE1NPC1RAB9AMAPTSMN1; SMN2 | |
| Ethylamine SCHEMBL6158093 | 0.71 | NPC1 (0.58) | BACE1NPC1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161932-B1 | PREPARATION OF CARBOXYPHENYLTHIOPHENYLACETIC ACIDS | MERCK & CO. INC. (US) | 1988-04-13 | — | — | EP | disclosed |
| US-4697037-A | DEPROTEINATION, CARBOXYLATION | MERCK & CO., INC. (US) | 1987-09-29 | — | — | US | disclosed |
| EP-0161932-A2 | Preparation of carboxyphenylthiophenylacetic acids | MERCK & CO. INC. (US) | 1985-11-21 | — | — | EP | disclosed |